Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].

Gallinamide A TFA 对 VeroE6 细胞的 CC_50 >100 μM，细胞毒性较低。Gallinamide A TFA (0.5 μM; 96 h) 通过抑制 CatL 介导的 SARS-CoV-2 内体进入 VeroE6 细胞[1]。Gallinamide A TFA 与 TMPRSS2 抑制剂 Nafamostat mesylate 表现出协同作用。在 HEK-ACE2-TMPRSS2 细胞中具有有效的抗病毒活性，但在 VeroE6 细胞系中无效[1]。