Anatabine dicitrate

Name: Anatabine dicitrate
Brand: TargetMol
SKU: T10318
Price: 987 USD
Availability: InStock
Rating: 4.5 (1 reviews)

还可以

产品编号 T10318

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein.

Anatabine dicitrate

还可以

产品编号 T10318

规格	价格	库存
5 mg	¥ 1,990	期货
10 mg	¥ 2,910	期货
50 mg	¥ 5,410	期货
100 mg	¥ 8,740	期货
200 mg	询价	期货
500 mg	询价	期货
1 mL x 10 mM (in DMSO)	¥ 2,480	期货

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产品介绍

生物活性

产品描述	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein.
体外活性	Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hours, Anatabine treatment shows dose-dependent inhibition of BACE-1 protein levels.Anatabine dose-dependently inhibits Aβ1-40 and Aβ1-42 (IC50: 640 μg/mL for both Aβ1-40 and Aβ1-42 in 7W CHO cells). Anatabine inhibits sAPPβ secretion without impacting sAPPα [1].
体内活性	Anatabine (0.5-2 mg/kg; i.p; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ1-40 and Aβ1-42 levels in a transgenic mouse model of Alzheimer's disease [1].

化学信息

分子量	544.46
分子式	C₂₂H₂₈N₂O₁₄
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 30 mg/mL (55.10 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8367 mL	9.1834 mL	18.3668 mL	91.8341 mL
5 mM	0.3673 mL	1.8367 mL	3.6734 mL	18.3668 mL
10 mM	0.1837 mL	0.9183 mL	1.8367 mL	9.1834 mL
20 mM	0.0918 mL	0.4592 mL	0.9183 mL	4.5917 mL
50 mM	0.0367 mL	0.1837 mL	0.3673 mL	1.8367 mL