HDAC1/MAO-B-IN-1

Name: HDAC1/MAO-B-IN-1
Brand: TargetMol
SKU: T60947
Rating: 4.5 (1 reviews)

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产品编号 T60947Cas号 2759855-37-1

HDAC1/MAO-B-IN-1 具有用于阿尔茨海默病研究的潜力。它是一种有效的、选择性的HDAC1/MAO-B 抑制剂，可以穿过血脑屏障。HDAC1/MAO-B-IN-1 对 HDAC1 和 MAO-B 的IC50值分别为 21.4 nM 和 99.0 nM。

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产品编号 T60947Cas号 2759855-37-1

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产品描述	HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1].
体外活性	HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC 50 s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively [1]. HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells [1]. Cell Viability Assay [1] Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production.
体内活性	HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability [1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice [1]. Animal Model: 6-8 weeks, ICR male mice [1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice [1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice.