(S)-Terazosin

Name: (S)-Terazosin
Brand: TargetMol
SKU: T12815
Price: 780 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T12815Cas号 109351-33-9

别名 (S)-特拉唑嗪

(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).

(S)-Terazosin

还可以

产品编号 T12815 别名 (S)-特拉唑嗪Cas号 109351-33-9

规格	价格	库存
2 mg	¥ 1,170	5日内发货
5 mg	¥ 1,980	5日内发货
25 mg	¥ 5,970	6-8周
50 mg	¥ 7,920	6-8周
100 mg	¥ 12,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 2,280	5日内发货

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产品介绍

生物活性

产品描述	(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).
靶点活性	α1A-adrenoceptor:ki： 3.91 nM , α1B-adrenoceptor:0.79 nM (ki), α1D-adrenoceptor:1.16 nM (ki), α2B-adrenoceptor:3.5 nM (ki), α2A-adrenoceptor: 729 nM (ki), α2C-adrenoceptor:46.4 nM (ki)
体外活性	(S)-Terazosin and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors, and showed potent α1-adrenoceptors antagonist in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate.
体内活性	(S)-Terazosin shows α2B receptor antagonist at rat atrial(pEC30 of 6.93). (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively.
别名	(S)-特拉唑嗪

化学信息

分子量	387.43
分子式	C₁₉H₂₅N₅O₄
CAS No.	109351-33-9
密度	1.332 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 150 mg/mL (387.17 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.5811 mL	12.9056 mL	25.8111 mL	129.0556 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL	25.8111 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL	12.9056 mL
20 mM	0.1291 mL	0.6453 mL	1.2906 mL	6.4528 mL
50 mM	0.0516 mL	0.2581 mL	0.5162 mL	2.5811 mL
100 mM	0.0258 mL	0.1291 mL	0.2581 mL	1.2906 mL