购物车
- 全部删除
- 您的购物车当前为空
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,170 | 5日内发货 | |
5 mg | ¥ 1,980 | 5日内发货 | |
25 mg | ¥ 5,970 | 6-8周 | |
50 mg | ¥ 7,920 | 6-8周 | |
100 mg | ¥ 12,500 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 2,280 | 5日内发货 |
产品描述 | (S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively). |
靶点活性 | α2C-adrenoceptor:46.4 nM (ki), α1B-adrenoceptor:0.79 nM (ki), α1A-adrenoceptor:ki: 3.91 nM , α2A-adrenoceptor: 729 nM (ki), α2B-adrenoceptor:3.5 nM (ki), α1D-adrenoceptor:1.16 nM (ki) |
体外活性 | (S)-Terazosin and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors, and showed potent α1-adrenoceptors antagonist in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate. |
体内活性 | (S)-Terazosin shows α2B receptor antagonist at rat atrial(pEC30 of 6.93). (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively. |
别名 | (S)-特拉唑嗪 |
分子量 | 387.43 |
分子式 | C19H25N5O4 |
CAS No. | 109351-33-9 |
密度 | 1.332 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 150 mg/mL (387.17 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.
评论内容