BMS-986120

Name: BMS-986120
Brand: TargetMol
SKU: T14684
Price: 565 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14684Cas号 1478712-37-6

BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].

BMS-986120

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产品编号 T14684Cas号 1478712-37-6

规格	价格	库存
2 mg	¥ 1,950	5日内发货
25 mg	¥ 10,700	10-14周
50 mg	¥ 13,900	10-14周
100 mg	¥ 21,800	10-14周

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产品介绍

生物活性

产品描述	BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
靶点活性	PAR4 (human):9.5 nM, PAR4 (monkey):2.1 nM
体外活性	BMS-986120 has high binding affinity to PAR4 expressed on HEK293 cells. And it inhibition of PAR4-induced calcium mobilization with an IC50 of 0.56 nM[3].
体内活性	BMS (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. In monkeys, BMS (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively[1].