Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, has an inhibitory effect on lipid peroxidation and is associated with the pathogenesis of gout joint disease and the formation of calcium oxalate stones.

Uric acid在400 μM浓度下作用于Caco-2细胞48小时，通过防止吲哚美辛引起的脂质过氧化作用，提供保护作用[2]。此外，细胞同时处理吲哚美辛和Uric acid钠（200 μM吲哚美辛加400 μMUric acid；24小时）显著降低了活性氧（ROS）水平，与仅用吲哚美辛处理的细胞相比。同时，暴露于吲哚美辛和Uric acid钠（200 μM吲哚美辛加400 μMUric acid；24小时）的Caco-2细胞的细胞活力，与仅用吲哚美辛处理的细胞相比有所提高。Uric acid钠对吲哚美辛引起的肠道细胞变化的保护效果，归因于其抗氧化活性[2]。

经口给予Uric acid sodium ，剂量为250 mg/kg，对吲哚美辛引起的小肠病变具有积极作用。它能改善由吲哚美辛所导致的小肠病变。Uric acid sodium 的口服治疗有助于减少小鼠吲哚美辛引起的小肠病变模型中空肠的ROS积累[2]。