BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) exhibiting an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity and potential for central nervous system (CNS) permeability, along with unique adaptability, rendering it a valuable tool for research into Alzheimer's disease (AD).

BCHE (human):3.8 nM

BChE-IN-16在IC 50超过10μM的情况下，对hAChE的抑制作用不明显[1]。该化合物是hBChE的竞争性抑制剂，其Ki值为4.04 nM[1]。在SH-SY5Y细胞系中，BChE-IN-16显示出细胞毒性，其IC 50为87.0μM[1]；同样，在HepG2细胞系中，其IC 50为76.0μM[1]。