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5J-4 是一种有效的钙释放激活钙通道 (CRAC) 和钙池操纵性钙内流(SOCE) 阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。
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5J-4 是一种有效的钙释放激活钙通道 (CRAC) 和钙池操纵性钙内流(SOCE) 阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 968 | 现货 | |
10 mg | ¥ 1,452 | 现货 | |
25 mg | ¥ 2,485 | 6-8周 | |
50 mg | ¥ 3,723 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 876 | 现货 |
产品描述 | 5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt. |
体内活性 | 5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation[1]. |
分子量 | 312.34 |
分子式 | C16H12N2O3S |
CAS No. | 827001-82-1 |
Smiles | OC1=CC=C2C(NC(=S)NC(=O)C3=CC=CO3)=CC=CC2=C1 |
密度 | 1.459 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (160.08 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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