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ASP8477是一种高效且选择性的FAAH抑制剂。该化合物通过口服活性能增加大脑中的阿纳米酰胺(anandamide)水平。在大鼠的神经病理性及骨关节炎疼痛模型中,ASP8477显示出良好的疗效,且不引起运动协调障碍。单次口服ASP8477能改善慢性压迫性神经损伤大鼠的热性痛觉过敏和寒冷痛觉异常。此外,ASP8477还能恢复由利血平引起的肌肉压力阈值下降的肌痛大鼠模型。研究表明,ASP8477在缓解神经病理性和功能性疼痛方面具有镇痛效果,其药理特性适合用于治疗慢性疼痛。
ASP8477是一种高效且选择性的FAAH抑制剂。该化合物通过口服活性能增加大脑中的阿纳米酰胺(anandamide)水平。在大鼠的神经病理性及骨关节炎疼痛模型中,ASP8477显示出良好的疗效,且不引起运动协调障碍。单次口服ASP8477能改善慢性压迫性神经损伤大鼠的热性痛觉过敏和寒冷痛觉异常。此外,ASP8477还能恢复由利血平引起的肌肉压力阈值下降的肌痛大鼠模型。研究表明,ASP8477在缓解神经病理性和功能性疼痛方面具有镇痛效果,其药理特性适合用于治疗慢性疼痛。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment. |
别名 | ASP-8477, ASP 8477 |
分子量 | 325.36 |
分子式 | C18H19N3O3 |
CAS No. | 906737-25-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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