CDK12-IN-4

Name: CDK12-IN-4
Brand: TargetMol
SKU: T40288
Price: 99 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T40288Cas号 2651196-69-7

别名 CDK12-IN-4

CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1).

CDK12-IN-4

还可以

产品编号 T40288 别名 CDK12-IN-4Cas号 2651196-69-7

规格	价格	库存	数量
25 mg	¥ 10,600	6-8周

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生物活性

产品描述	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1).
靶点活性	CDK9-CyclinT1:>20 μM (IC50), CDK2-CyclinE:>20 μM (IC50), CDK12:0.641 μM (IC50)
体外活性	CDK12-IN-4 (Example 172) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC 50 =0.626 nM) and has no effect on CAL-120 cells[1]. CDK12-IN-4 has antproliferative activity in MDA-MB-231 cells (IC 50 =0.535 nM) and CAL-120 cells (IC 50 =2.43 nM)[1]. CDK12-IN-4 has a inhibition IC 50 CDK12 high ATP to Degradation DC 50 CDK12 ratio of 581[1].
别名	CDK12-IN-4