Nisoldipine

Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂，IC50=10 nM。

产品编号 T0163Cas号 63675-72-9

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Nisoldipine

产品编号 T0163别名 尼索地平, BAY-k 5552Cas号 63675-72-9

Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂，IC50=10 nM。

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规格	价格	库存
50 mg	¥ 327	现货
100 mg	¥ 460	现货
500 mg	¥ 798	现货
1 g	¥ 1,347	现货

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"Nisoldipine"的相关化合物库

产品介绍

生物活性

产品描述	Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
靶点活性	Cav 1.2, L-type:10 nM
体外活性	对于Timothy综合征病人,Nisoldipine（IC50=267 nM）通过抑制钙离子从L型钙通道流入,降低动脉平滑肌收缩性及随后的血管收缩 , 导致血管舒张,且降低血压.
体内活性	在豚鼠心室肌细胞中,Nisoldipine延迟整流K+通道,快速激活延迟整流K+通道抑制IKr(IC50=23 μM), 及缓慢激活延迟整流K+通道抑制IKs(IC50=40 μM)。
激酶实验	Binding experiments of electrophysiology: CHO cells expressing the subunit of the voltage-dependent L-type Ca2+ channel are cultrured in medium without serum in the presence of different concentrations of Nisoldipine. Then Ca2+ channel current elicited from a holding potential of -100 mV or -50 mV is recorded at room temperature with the whole-cell configuration of the patch-clamp method using the List EPC-7 patch-clamp amplifer and pClamp software. The concentration of competitor inhibiting 50% of the specific binding represents IC50.
细胞实验	The myocytes are bathed in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, tail currents are recorded on repolarisations to -40mV. The myocytes are exposed to 10-100 mM Nisoldipine for 8-10 minutes. Then the whole-cell membrane currents are recorded using an EPC-7 amplifier.(Only for Reference)
别名	尼索地平, BAY-k 5552

化学信息

分子量	388.41
分子式	C₂₀H₂₄N₂O₆
CAS No.	63675-72-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

Ethanol: 56 mg/mL (144.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (128.73 mM)

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5746 mL	12.8730 mL	25.7460 mL	128.7300 mL
5 mM	0.5149 mL	2.5746 mL	5.1492 mL	25.7460 mL
10 mM	0.2575 mL	1.2873 mL	2.5746 mL	12.8730 mL
20 mM	0.1287 mL	0.6436 mL	1.2873 mL	6.4365 mL
50 mM	0.0515 mL	0.2575 mL	0.5149 mL	2.5746 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	1.2873 mL