KH-259

Name: KH-259
Brand: TargetMol
SKU: T61073
Rating: 4.5 (1 reviews)

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产品编号 T61073

KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259 holds promise as a valuable tool for neurodegenerative diseases research [1].

KH-259

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产品编号 T61073

规格	价格	库存
25 mg	¥ 10,600	10-14周
50 mg	¥ 13,800	10-14周
100 mg	¥ 17,500	10-14周

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产品描述	KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259 holds promise as a valuable tool for neurodegenerative diseases research [1].
体外活性	KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes [1].
体内活性	KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain [1].