Tubulin polymerization-IN-24

Name: Tubulin polymerization-IN-24
Brand: TargetMol
SKU: T60936
Price: 377 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T60936Cas号 564468-51-5

Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的微管蛋白聚合抑制剂，可提高 GTP 水解速率并抑制微管组装。Tubulin aggregation-IN-24 诱导细胞凋亡和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 抑制乳腺癌细胞 MCF-7 的增殖。

Tubulin polymerization-IN-24

还可以

产品编号 T60936Cas号 564468-51-5

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述

Tubulin polymerization-IN-24 (compound HMBA) is a potent inhibitor of tubulin polymerization that increase the GTP hydrolysis rate and inhibits microtubule assembly. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest in G2/M phase. Tubulin polymerization-IN-24 inhibits proliferation of MCF-7 cells [1].

体外活性

Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner [1]. Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC 50 value of 47 nM [1]. Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a K i value of 3.6 μM [1]. Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway [1].