购物车
- 全部删除
- 您的购物车当前为空
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。
为众多的药物研发团队赋能,
让新药发现更简单!
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 186 | 现货 | |
5 mg | ¥ 398 | 现货 | |
10 mg | ¥ 563 | 现货 | |
25 mg | ¥ 1,080 | 现货 | |
50 mg | ¥ 1,970 | 现货 | |
100 mg | ¥ 2,480 | 现货 | |
200 mg | ¥ 3,720 | 现货 | |
500 mg | ¥ 5,880 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 449 | 现货 |
产品描述 | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes. |
靶点活性 | ERG (human):1 µM |
分子量 | 231.04 |
分子式 | C8H4Cl2N2O2 |
CAS No. | 18711-16-5 |
Smiles | ON=C1C(=O)Nc2c1ccc(Cl)c2Cl |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (194.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.
评论内容