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BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
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BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 495 | 5日内发货 | |
5 mg | ¥ 828 | 6-8周 | |
10 mg | ¥ 1,580 | 6-8周 | |
100 mg | ¥ 6,990 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 913 | 6-8周 |
产品描述 | BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1]. |
靶点活性 | Fas:79 nM |
体外活性 | BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM and it shows no significant LDH release in the cytotoxicity assay up to 30 μM[1]. |
体内活性 | BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1]. |
别名 | BI99179 |
分子量 | 391.46 |
分子式 | C23H25N3O3 |
CAS No. | 1291779-76-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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