Liarozole dihydrochloride

Name: Liarozole dihydrochloride
Brand: TargetMol
SKU: T11847
Rating: 4.5 (1 reviews)

还可以

产品编号 T11847Cas号 1883548-96-6

别名 R75251 dihydrochloride

Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

Liarozole dihydrochloride

还可以

产品编号 T11847 别名 R75251 dihydrochlorideCas号 1883548-96-6

规格	价格	库存	数量
10 mg	¥ 4,460	35日内发货

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
靶点活性	CYP26:7 μM (IC50)
体外活性	Liarozole inhibits 17a-hydroxylase activity in bovine adrenal microsomes (IC50=0.15 μM) [1]. Liarozole has modest inhibitory activity on cholesterol synthesis in human hepatoma cells(IC50=5 μM)[1].Liarozole inhibits the metabolism of retinoic acid to more polar metabolites in hamster liver microsomes (IC50=2.2 μM), rat liver homogenate (IC50=0.14 μM), dunning prostate cancer homogenate (IC50=0.26 μM) and MCF-7 human breast cancer cells (almost complete block at 10μM) [1].
别名	R75251 dihydrochloride

化学信息

分子量	381.69
分子式	C₁₇H₁₅Cl₃N₄
CAS No.	1883548-96-6
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (131.00 mM), Sonication is recommended.

H2O: 50 mg/mL (131.00 mM)

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.6199 mL	13.0996 mL	26.1993 mL	130.9964 mL
5 mM	0.5240 mL	2.6199 mL	5.2399 mL	26.1993 mL
10 mM	0.2620 mL	1.3100 mL	2.6199 mL	13.0996 mL
20 mM	0.1310 mL	0.6550 mL	1.3100 mL	6.5498 mL
50 mM	0.0524 mL	0.2620 mL	0.5240 mL	2.6199 mL
100 mM	0.0262 mL	0.1310 mL	0.2620 mL	1.3100 mL