ALK/ROS1-IN-1

Name: ALK/ROS1-IN-1
Brand: TargetMol
SKU: T10286
Rating: 4.5 (1 reviews)

还可以

产品编号 T10286Cas号 2365497-07-8

ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).

还可以

产品编号 T10286Cas号 2365497-07-8

ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).

大包装 & 定制

加入购物车

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。但由于客观因素，研发中会存在小概率合成不成功的情况，还请理解，如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品介绍

生物活性

产品描述	ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).
靶点活性	ALK:0.174 μM , ROS1:0.530 μM
体外活性	ALK/ROS1-IN-1 (compound 2e) displays potent anti-proliferative activity against ALK-addicted H3122 (IC50: 6.27 μM) and ROS1-addicted HCC78 cell lines (IC50: 10.71 μM). ALK/ROS1-IN-1 shows impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M (IC50: 41.3 nM). ALK/ROS1-IN-1 shows potent inhibitory activity in Ba/F3 cell line expressing ROS1 mutants (IC50s: 137.7, 104.7 nM, and 233.9 for wide-type, G2032R mutant and L2026M mutant). ALK/ROS1-IN-1 has no significant effect on inducing apoptosis of the HCC78 cell line.