HSD17B13-IN-16 (compound 8) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), demonstrating an IC50 of <0.1 μM and <1 μM when using estradiol and Leukotriene B3 as substrates, respectively. The compound is notably significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].
化学信息
分子量
416.88
分子式
C20H17ClN2O4S
CAS No.
2758802-09-2
储存&溶解度
存储
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.