N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Acetyl lysyltyrosylcysteine amide attenuates neuronal damage and preserves brain tissue and neurological function in the post-stroke brain.N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration and LDL oxidation.N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, and specific agent. N-Acetyl lysyltyrosylcysteine amide is used in the study of bronchial dysplasia.

N-Acetyl lysyltyrosylcysteine amide（KYC）（10 mg/kg；i.p.；每日一次，持续3-7天；C57BL/6J小鼠）在MCAO小鼠中显著降低神经严重性评分和梗死大小。[1] N-Acetyl lysyltyrosylcysteine amide（10 mg/kg；i.p.；每日一次，连续7天）显著保护BBB功能并减少中性粒细胞浸润。[1] N-Acetyl lysyltyrosylcysteine amide（10 mg/kg；i.p.；每日一次，连续7天；C57BL/6J小鼠）显著减少MCAO小鼠中的微胶质/巨噬细胞激活和神经元损失。[1] N-Acetyl lysyltyrosylcysteine amide（10 mg/kg；i.p.；每日一次，持续3-7天；C57BL/6J小鼠）减少MCAO小鼠大脑中的凋亡和细胞损伤。[1] N-Acetyl lysyltyrosylcysteine amide减少了MCAO小鼠大脑中的MPO、NO2Tyr和4-HNE水平。N-Acetyl lysyltyrosylcysteine amide在中脑动脉闭塞（MCAO）小鼠大脑中显著减少梗塞大小、血脑屏障泄露、髓样细胞浸润、神经元损失和凋亡。[1]