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GSK-3β inhibitor 6

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产品编号 T61804

GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].

GSK-3β inhibitor 6

GSK-3β inhibitor 6

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产品编号 T61804

GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].

规格价格库存数量
25 mg¥ 10,60010-14周
50 mg¥ 13,80010-14周
100 mg¥ 17,50010-14周
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产品介绍

生物活性
产品描述
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
体外活性
GSK-3β inhibitor 6 (Compound B30, 0-30 μΜ, 30 min) shows good GSK-3β kinase inhibitory activity (IC 50 : 24.4 μM) [1]. GSK-3β inhibitor 6 (5 μM, 3 h) shows high hepatocyte glucose uptake (38%) with no significant toxicity against HepG2 cells [1].
体内活性
GSK-3β inhibitor 6 (Compound 5k, oral administration, 20 mg/kg) shows favorable drug-like properties (t 1/2 : 1.41 h, C max : 288 ng/mL) [2]. Animal Model: Sprague-Dawley rats (pharmacokinetic assay) [2] Dosage: 2 mg/kg, 20 mg/kg Administration: Intravenous injection (2 mg/kg), oral administration (20 mg/kg) Result: Pharmacokinetic profile of GSK-3β inhibitor 6 (Compound 5k). Compound Route Dose (mg/kg) t 1/2 (h) Tmax (h) C max (ng/mL) AUC 0-t (hr ng/mL) AUC 0-∞ (hr ng/mL) CL (mL/hr/kg) F (%) GSK-3β inhibitor 6 Oral administration 20 1.41 1.33 288 1030 1073 18719 11.4 GSK-3β inhibitor 6 Intravenous injection 2 2.13 0.08 449 872.89 940.48 2190.83 F: oral bioavailability.
化学信息
分子量393.28
分子式C20H17BrN4
储存&溶解度
存储Shipping with blue ice.

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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