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GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | |
50 mg | ¥ 13,800 | 10-14周 | |
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1]. |
体外活性 | GSK-3β inhibitor 6 (Compound B30, 0-30 μΜ, 30 min) shows good GSK-3β kinase inhibitory activity (IC 50 : 24.4 μM) [1]. GSK-3β inhibitor 6 (5 μM, 3 h) shows high hepatocyte glucose uptake (38%) with no significant toxicity against HepG2 cells [1]. |
体内活性 | GSK-3β inhibitor 6 (Compound 5k, oral administration, 20 mg/kg) shows favorable drug-like properties (t 1/2 : 1.41 h, C max : 288 ng/mL) [2]. Animal Model: Sprague-Dawley rats (pharmacokinetic assay) [2] Dosage: 2 mg/kg, 20 mg/kg Administration: Intravenous injection (2 mg/kg), oral administration (20 mg/kg) Result: Pharmacokinetic profile of GSK-3β inhibitor 6 (Compound 5k). Compound Route Dose (mg/kg) t 1/2 (h) Tmax (h) C max (ng/mL) AUC 0-t (hr ng/mL) AUC 0-∞ (hr ng/mL) CL (mL/hr/kg) F (%) GSK-3β inhibitor 6 Oral administration 20 1.41 1.33 288 1030 1073 18719 11.4 GSK-3β inhibitor 6 Intravenous injection 2 2.13 0.08 449 872.89 940.48 2190.83 F: oral bioavailability. |
分子量 | 393.28 |
分子式 | C20H17BrN4 |
存储 | Shipping with blue ice. |
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