GDC-0310

Name: GDC-0310
Brand: TargetMol
SKU: T39208
Rating: 4.5 (1 reviews)

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产品编号 T39208Cas号 1788063-52-4

GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, exhibiting a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.

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GDC-0310

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产品编号 T39208Cas号 1788063-52-4

GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, exhibiting a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.

规格	价格	库存
1 mg	¥ 1,250	8-10周
5 mg	¥ 2,970	8-10周
10 mg	¥ 4,580	8-10周
25 mg	¥ 7,270	8-10周
50 mg	¥ 9,790	8-10周
100 mg	¥ 13,200	8-10周

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产品描述	GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, exhibiting a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.
靶点活性	Nav1.5 (human):551 nM (IC50), Nav1.2 (human):38 nM (IC50), Nav1.4 (human):3.4 nM (IC50), Nav1.1 (human):202 nM (IC50), Nav1.6 (human):198 nM (IC50)
体外活性	GDC-0310 exhibits an EC 50 of 1.1 μM in vivo and a K i of 1.8 nM for Na v 1.7[1].
体内活性	GDC-0310 shows substantially improved Na v selectivity and ADME properties[1]. GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively[1].