CBB1007

Name: CBB1007
Brand: TargetMol
SKU: T10699L
Rating: 4.5 (1 reviews)

还可以

产品编号 T10699LCas号 1379573-92-8

CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).

CBB1007

还可以

产品编号 T10699LCas号 1379573-92-8

CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).

规格	价格	库存
25 mg	¥ 15,000	8-10周
50 mg	¥ 19,800	8-10周
100 mg	¥ 25,500	8-10周

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生物活性

产品描述

CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).

体外活性

CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM). hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).