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Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂,也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA,PTP1B,HPTPβ和SHP2的IC50分别为 126 nM,109 nM,26 nM 和 201 nM。
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Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂,也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA,PTP1B,HPTPβ和SHP2的IC50分别为 126 nM,109 nM,26 nM 和 201 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 328 | 现货 | |
10 mg | ¥ 497 | 现货 | |
25 mg | ¥ 997 | 现货 | |
50 mg | ¥ 1,570 | 现货 | |
100 mg | ¥ 2,330 | 现货 | |
200 mg | ¥ 3,480 | 现货 | |
500 mg | ¥ 5,560 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 363 | 现货 |
产品描述 | Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2]. |
靶点活性 | SHP2:201 nM (IC50), HPTPβ:26 nM (IC50), PTP1B:109 nM (IC50), HCPTPA:126 nM (IC50) |
体外活性 | BMOV处理增强了胰岛素受体及胰岛素信号传导关键中介Akt的磷酸化。BMOV处理还导致C2C12细胞中葡萄糖摄取的增加[1]。 |
体内活性 | BMOV (0.75-3.0 mmol;经腹腔注射;每周两次;为期6周;雄性C57BL/6J小鼠)处理明显改善了代谢表型,表现为体重降低、胰岛素敏感性增强及葡萄糖耐量改善。 |
动物实验 | BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
别名 | 双(麦芽醇)氧钒(IV), BMOV, Bis(maltolato)oxovanadium (IV), Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium |
分子量 | 317.15 |
分子式 | C12H10O7V |
CAS No. | 38213-69-3 |
Smiles | O=[V+2]12([O-]C=3C(=O1)C=COC3C)[O-]C=4C(=O2)C=COC4C |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 13 mg/mL (40.99 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
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