Atuveciclib S-Enantiomer

Name: Atuveciclib S-Enantiomer
Brand: TargetMol
SKU: T10465
Rating: 4.5 (1 reviews)

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产品编号 T10465Cas号 2250279-81-1

别名 BAY-1143572 S-Enantiomer

Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是 BAY-1143572的 S-对映异构体，是一种有效的选择性 CDK9抑制剂，抑制 CDK9/CycT1，IC50为 16 nM。

Atuveciclib S-Enantiomer

还可以

产品编号 T10465 别名 BAY-1143572 S-EnantiomerCas号 2250279-81-1

Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是 BAY-1143572的 S-对映异构体，是一种有效的选择性 CDK9抑制剂，抑制 CDK9/CycT1，IC50为 16 nM。

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产品介绍

生物活性

产品描述	Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM.
靶点活性	CDK9-CyclinT1:16 nM
体外活性	Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties compared with Atuveciclib (BAY-1143572), well within the limits of measurement accuracy. However, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC 50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC 50 : 1100 nM) [1].
体内活性	Atuveciclib (BAY-1143572) S-Enantiomer shows blood/plasma ratios of about 1. Relative to Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar rat PK properties in vivo (CL b : 1.2 L/kg per hour, V ss : 1.2 L/kg, t 1/2 : 0.6 h, F: 53 %) [1].
别名	BAY-1143572 S-Enantiomer

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 113 mg/mL (291.67 mM)

溶液配制表

DMSO