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Monoamine OxidaseB inhibitor 4 (compound 1l) 作为一种选择性hMAO-B抑制剂,显示了显著的生物活性(IC50=8.3 nM)。该化合物不仅表现出抗神经炎症作用,其神经毒性也相对较低。此外,Monoamine OxidaseB inhibitor 4有效阻断了LPS和Aβ1-42引起的NO、TNF-α和IL-1β的释放,并能减轻Aβ(1-42)诱导的细胞毒性。
Monoamine OxidaseB inhibitor 4 (compound 1l) 作为一种选择性hMAO-B抑制剂,显示了显著的生物活性(IC50=8.3 nM)。该化合物不仅表现出抗神经炎症作用,其神经毒性也相对较低。此外,Monoamine OxidaseB inhibitor 4有效阻断了LPS和Aβ1-42引起的NO、TNF-α和IL-1β的释放,并能减轻Aβ(1-42)诱导的细胞毒性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Monoamine Oxidase B Inhibitor 4 (compound 1l), with a potent IC50 value of 8.3 nM, is a selective human monoamine oxidase-B (hMAO-B) inhibitor. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. It effectively inhibits the release of NO, TNF-α, and IL-1β induced by LPS and Aβ1-42, and additionally mitigates the cytotoxic effects triggered by Aβ(1-42) . |
分子量 | 324.16 |
分子式 | C15H11Cl2NO3 |
CAS No. | 424794-91-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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