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Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.
Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 15,000 | 8-10周 | |
50 mg | ¥ 19,800 | 8-10周 | |
100 mg | ¥ 25,500 | 8-10周 |
产品描述 | Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. |
体外活性 | Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. A significant agonistic effect is observed in the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression. |
体内活性 | Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose-dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene prevents loss of bone due to ovariectomy with maximal efficacy observed at 0.1-1 mg/kg/day ( ED50: about 0.01 mg/kg). Arzoxifene antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels (ED50: 0.03 mg/kg/day). |
别名 | SERM 3, LY 353381 HCl |
分子量 | 512.06 |
分子式 | C28H30ClNO4S |
CAS No. | 182133-27-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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