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VEGFR-2-IN-36(compound 15)是一种具有抗癌活性的VEGFR-2抑制剂(IC50:0.067 μM)和凋亡诱导剂。该化合物能够上调BAX水平和下调Bcl-2水平,对MCF-7(IC50=0.42 μM)和HepG2(IC50=0.22 μM)癌细胞展现出明显的毒性效果。
VEGFR-2-IN-36(compound 15)是一种具有抗癌活性的VEGFR-2抑制剂(IC50:0.067 μM)和凋亡诱导剂。该化合物能够上调BAX水平和下调Bcl-2水平,对MCF-7(IC50=0.42 μM)和HepG2(IC50=0.22 μM)癌细胞展现出明显的毒性效果。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated anticancer efficacy. It modulates apoptotic pathways by upregulating BAX and downregulating Bcl-2, leading to cytotoxic effects on cancer cell lines, including MCF-7 (IC50 = 0.42 μM) and HepG2 (IC50 = 0.22 μM) [1]. |
分子量 | 489.48 |
分子式 | C24H23N7O5 |
存储 | Shipping with blue ice. |
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