OSK-1

Name: OSK-1
Brand: TargetMol
SKU: T39283
Rating: 4.5 (1 reviews)

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产品编号 T39283Cas号 183815-75-0

OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug.

OSK-1

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产品编号 T39283Cas号 183815-75-0

规格	价格	库存	数量
25 mg	¥ 10,600	期货

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产品介绍

生物活性

产品描述	OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug.
靶点活性	Kv1.2:5.4 nM (IC50), Kv1.1:0.6 nM (IC50), Kv1.3:0.014 nM (IC50), KCa3.1:225 nM (IC50)
体外活性	OSK1 has no effect on K Ca 2.1, K Ca 2.2, K Ca 2.3 and K Ca 1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on K Ca 3.1 channel (also referred to as IK1 or SK4) with an IC 50 value of 225 nM[1].
体内活性	OSK1 is lethal in mice by intracerebroventricular injection, with a LD 50 (50% lethal dose) value of 2 μg/kg[1].