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IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 591 | 5日内发货 | |
5 mg | ¥ 997 | 5日内发货 | |
25 mg | ¥ 4,150 | 5日内发货 | |
50 mg | ¥ 5,400 | 5日内发货 | |
100 mg | ¥ 7,490 | 5日内发货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,290 | 5日内发货 |
产品描述 | IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo. |
别名 | IACS-10759, IACS10759, IACS-010759 HCl, IACS-010759, IACS 10759 |
分子量 | 599.03 |
分子式 | C25H26ClF3N6O4S |
CAS No. | 1807523-99-4 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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