购物车
- 全部删除
- 您的购物车当前为空
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 15,000 | 8-10周 | |
50 mg | ¥ 19,800 | 8-10周 | |
100 mg | ¥ 25,500 | 8-10周 |
产品描述 | MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM). |
靶点活性 | MARK:5 nM |
体外活性 | MARK-IN-2 inhibits MARK3 with an IC50 of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC50 of 280 nM.MARK-IN-2 is a potent MARK inhibitor.?Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. |
体内活性 | MARK-IN-2 has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) .Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. |
分子量 | 425.88 |
分子式 | C18H18ClF2N5OS |
CAS No. | 1314893-26-9 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
评论内容