mGluR2 antagonist 1

Name: mGluR2 antagonist 1
Brand: TargetMol
SKU: T38910
Rating: 4.5 (1 reviews)

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产品编号 T38910Cas号 1432728-49-8

mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.

mGluR2 antagonist 1

还可以

产品编号 T38910Cas号 1432728-49-8

规格	价格	库存
5 mg	¥ 4,280	6-8周
25 mg	¥ 15,000	6-8周
50 mg	¥ 19,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 4,320	6-8周

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生物活性

产品描述	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.
靶点活性	mGluR2:9 nM (IC50)
体内活性	In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg.