BCL6-IN-8c

Name: BCL6-IN-8c
Brand: TargetMol
SKU: T14515
Price: 335 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14515Cas号 2130878-25-8

BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay).

BCL6-IN-8c

还可以

产品编号 T14515Cas号 2130878-25-8

BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay).

规格	价格	库存	数量
5 mg	¥ 7,000	5日内发货

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产品介绍

生物活性

产品描述	BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay).
靶点活性	BCL6-corepressor interaction:0.10 μM
体外活性	BCL6-IN-8c (Compound 8c) exhibits good cellular PPI inhibitory activity in the submicromolar range (M2H IC50 = 0.72 μM). BCL6-IN-8c can not exhibit significant cytotoxicity even at 30 μM[1].
体内活性	BCL6-IN-8c exhibits a good pharmacokinetic profile (Cmax = 233 ng/mL, Tmax = 2 hours, MRT = 3.3 h, AUC = 1.27 mg?h/mL, F (oral bioavailability) = 79.9%)[1]. The pharmacokinetic profile of BCL6-IN-8c (Compound 8c) is evaluated by a mouse cassette-dosing study (0.1 mg/kg iv; 1 mg/kg po).