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TC-I 2014 是一种口服有效的、强效的、苯并咪唑类的、 TRPM8 的拮抗剂,其对犬类、人和大鼠通道的 IC50 值分别为 0.8 nM, 3.0 nM 和 4.4 nM。在疼痛动物模型中具有抗痛觉超敏作用。
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TC-I 2014 是一种口服有效的、强效的、苯并咪唑类的、 TRPM8 的拮抗剂,其对犬类、人和大鼠通道的 IC50 值分别为 0.8 nM, 3.0 nM 和 4.4 nM。在疼痛动物模型中具有抗痛觉超敏作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 786 | 现货 | |
5 mg | ¥ 1,990 | 现货 | |
10 mg | ¥ 3,180 | 现货 | |
25 mg | ¥ 5,780 | 现货 | |
50 mg | ¥ 8,280 | 现货 | |
100 mg | ¥ 11,300 | 现货 | |
500 mg | ¥ 22,800 | 现货 |
产品描述 | TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively). |
体外活性 | TC-I 2014 effectively inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8 (IC50: 0.413 and 1 nM, respectively) [1]. |
体内活性 | TC-I 2014 (10 mg/kg, Orally once) fully avoids icilin-induced WDS [1]. |
分子量 | 467.41 |
分子式 | C23H19F6N3O |
CAS No. | 1221349-53-6 |
Smiles | FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F |
密度 | 1.48 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 225.0 mg/mL (481.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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