PD 123319 ditrifluoroacetate

Name: PD 123319 ditrifluoroacetate
Brand: TargetMol
SKU: T12381
Rating: 4.5 (1 reviews)

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产品编号 T12381Cas号 136676-91-0

PD 123319 (ditrifluoroacetate) is a potent and selective antagonist of AT2 angiotensin II receptor(IC50 of 34 nM).

还可以

产品编号 T12381Cas号 136676-91-0

PD 123319 (ditrifluoroacetate) is a potent and selective antagonist of AT2 angiotensin II receptor(IC50 of 34 nM).

规格	价格	库存	数量
10 mg	¥ 921	期货

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产品介绍

生物活性

产品描述	PD 123319 (ditrifluoroacetate) is a potent and selective antagonist of AT2 angiotensin II receptor(IC50 of 34 nM).
靶点活性	AT2 receptor:34 nM
体外活性	PD-123319 did not have any effect on 125I-All binding to this site.?The second class of binding sites was more sensitive to PD-123319, with an IC50 of 6.9 +/- 3.7 nM, and had a much lower affinity for DuP-753 (IC50 around 10 microM).?The two classes of receptors had different affinities for All.?All showed an affinity around 2 nM for All type 1 receptor (AT1)(DuP-753 sensitive) and a higher affinity, around 0.3 nM, for All type 2 receptor (AT2) (PD-123319 sensitive).?All-induced steroidogenesis was completely abolished in the presence of 3 microM DuP-753, indicating that this activity was mediated through a DuP-753-sensitive receptor.

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 36 mg/mL (48.87 mM)

溶液配制表

H2O