FMK-MEA

Name: FMK-MEA
Brand: TargetMol
SKU: T11310
Rating: 4.5 (1 reviews)

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产品编号 T11310Cas号 1414811-15-6

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

还可以

产品编号 T11310Cas号 1414811-15-6

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

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产品介绍

生物活性

产品描述	FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
体外活性	FMK-MEA treatment inhibits RSK2 kinase activity in diverse, highly invasive human cancer cell lines including 212LN, M4e, A549, and SKBR3 cells.?Treatment with the RSK-specific inhibitor FMK-MEA significantly attenuates RSK2 activity, as assessed by the phosphorylation levels of Ser-386 and the consequent invasive ability of A549 cells.FMK-MEA is a water-soluble derivative of fmk.
体内活性	FMK-MEA treatment has no effect on the tumor size, and the proliferation rate of the primary tumor.FMK-MEA treatment (80 mg/kg/day for 16 days by intraperitoneal injection) in highly metastatic M4e cell xenograft nude mice results in a significant attenuation of LN metastasis.