Taltobulin trifluoroacetate

Name: Taltobulin trifluoroacetate
Brand: TargetMol
SKU: T13073
Price: 369 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T13073Cas号 228266-41-9

别名 HTI-286 trifluoroacetate, SPA-110 trifluoroacetate

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin trifluoroacetate

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产品编号 T13073 别名 HTI-286 trifluoroacetate, SPA-110 trifluoroacetateCas号 228266-41-9

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

规格	价格	库存	数量
2 mg	¥ 1,750	5日内发货

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产品介绍

生物活性

产品描述	Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
体外活性	The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM).
体内活性	In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively.
别名	HTI-286 trifluoroacetate, SPA-110 trifluoroacetate

化学信息

分子量	587.681
分子式	C₂₉H₄₄F₃N₃O₆
CAS No.	228266-41-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 39 mg/mL (66.36 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7016 mL	8.5080 mL	17.0160 mL	85.0802 mL
5 mM	0.3403 mL	1.7016 mL	3.4032 mL	17.0160 mL
10 mM	0.1702 mL	0.8508 mL	1.7016 mL	8.5080 mL
20 mM	0.0851 mL	0.4254 mL	0.8508 mL	4.2540 mL
50 mM	0.0340 mL	0.1702 mL	0.3403 mL	1.7016 mL