CDK5 inhibitor 20-223

Name: CDK5 inhibitor 20-223
Brand: TargetMol
SKU: T36742
Rating: 4.5 (1 reviews)

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产品编号 T36742Cas号 865317-30-2

别名 CDK5 inhibitor 20-223

CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].

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CDK5 inhibitor 20-223

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产品编号 T36742 别名 CDK5 inhibitor 20-223Cas号 865317-30-2

CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].

规格	价格	库存
2 mg	¥ 987	5日内发货
5 mg	¥ 1,740	5日内发货
25 mg	¥ 5,970	6-8周
50 mg	¥ 7,920	6-8周
100 mg	¥ 12,200	6-8周
1 mL x 10 mM (in DMSO)	¥ 1,830	5日内发货

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生物活性

产品描述	CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
靶点活性	CDK2:6.0 nM (IC50), CDK5:8.8 nM (IC50)
体外活性	CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines[1].CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines[1]. Cell Viability Assay[1] Cell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells
体内活性	CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1]. Animal Model: Athymic nude mice[1]
别名	CDK5 inhibitor 20-223