购物车
- 全部删除
- 您的购物车当前为空
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 15,000 | 10-14周 | |
50 mg | ¥ 19,800 | 10-14周 | |
100 mg | ¥ 25,500 | 10-14周 |
产品描述 | ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines). |
靶点活性 | Tropomyosin (human melanoma cell lines):3.83-6.84 μM |
体内活性 | The maximal tolerance dose (MTD) for TR100 and ATM-3507 is 60 and 150 mg/kg, respectively. The median survival of mice increased from 18 days for mice treated with ATM-3507 to more than 49 days for mice treated with the combination. It is also found that twice-weekly intravenous administration of ATM-3507 also shows combination efficacy. The impact of each treatment or the combination of body weight is minimal. Drug levels are measured following the intravenous administration of ATM-3507 at 30 mg/kg in Balb/c mice (n=3 per time point). The mean half-life of ATM-3507 is 5.01 hrs for the terminal elimination phase. The mean AUC0-t in the plasma is 14,548 ng/h/mL. The Cmax of ATM-3507 is 5,758 ng/mL and the t1/2 is 5.01 h. The observed plasma clearance and volume of distribution at steady state of ATM-3507 is 33.8 mL/min/kg and 7.23 L/kg, respectively. |
别名 | ATM-3507 trihydrochloride |
分子量 | 721.17 |
分子式 | C37H49Cl3FN5O2 |
密度 | 1.31g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 250 mg/mL (346.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
|
评论内容