SCD1-IN-1

Name: SCD1-IN-1
Brand: TargetMol
SKU: T61841
Price: 732 USD
Availability: InStock
Rating: 4.5 (1 reviews)

还可以

产品编号 T61841Cas号 1111078-63-7

SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].

还可以

产品编号 T61841Cas号 1111078-63-7

SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].
体外活性	SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC 50 value of 6.8 nM [1].
体内活性	SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model [1]. Animal Model: Hamster ear model [1] Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. Administration: Applied to ~3 cm 2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.