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MEK/RAF-IN-1 (Compound 16b) 作为一种针对MEK和RAF的抑制剂,其针对MEK1、BRAF和BRAFV600E的IC50值分别仅为28、3和3 nM。该化合物表现出明显的抗肿瘤效果,能够有效抑制体外MIA PaCa-2 (G12C KRAS)、HCT116 (G13D KRAS) 以及 C26 (G12D KRAS) 细胞的增殖,并在异种移植的结直肠癌小鼠模型中显著抑制肿瘤生长。
MEK/RAF-IN-1 (Compound 16b) 作为一种针对MEK和RAF的抑制剂,其针对MEK1、BRAF和BRAFV600E的IC50值分别仅为28、3和3 nM。该化合物表现出明显的抗肿瘤效果,能够有效抑制体外MIA PaCa-2 (G12C KRAS)、HCT116 (G13D KRAS) 以及 C26 (G12D KRAS) 细胞的增殖,并在异种移植的结直肠癌小鼠模型中显著抑制肿瘤生长。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer. |
靶点活性 | B-Raf (V600E):3 nM, B-Raf:3 nM, MEK1:28 nM |
分子量 | 618.63 |
分子式 | C28H29F3N6O5S |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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