Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1]

Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2]