CAY10580

Name: CAY10580
Brand: TargetMol
SKU: T40738
Rating: 4.5 (1 reviews)

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产品编号 T40738Cas号 64054-40-6

别名 CAY10580

CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).

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产品编号 T40738 别名 CAY10580Cas号 64054-40-6

CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).

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生物活性

产品描述	CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).
靶点活性	EP4:35 nM (Ki), EP4 receptor:35 nM (Ki), EP3 receptor:2000 nM (Ki), EP2 receptor:3000 nM (Ki)
体外活性	CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].
体内活性	CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. Animal Model: Six-week old male EP4 +/+ mice (Treating high fat diet-challenged mice)[3]Dosage: 200 μg/kg body weight Administration: Intraperitoneal injection; daily for remaining three weeks Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
别名	CAY10580