WAY-100135 dihydrochloride

Name: WAY-100135 dihydrochloride
Brand: TargetMol
SKU: T38975
Rating: 4.5 (1 reviews)

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产品编号 T38975Cas号 149055-79-8

WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.

WAY-100135 dihydrochloride

还可以

产品编号 T38975Cas号 149055-79-8

规格	价格	库存	数量
2 mg	¥ 1,450	5日内发货

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生物活性

产品描述	WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.
靶点活性	5-HT1A receptor:34 nM (IC50)
体外活性	WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA 2 of 7.2[1]. WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2].
体内活性	WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1]. WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2].