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Bexagliflozin,又称EGT1442,是一种高效且选择性的SGLT2抑制剂,能够降低db/db小鼠的血糖和HbA(1c)水平,同时延长易患中风大鼠的存活时间。EGT1442针对人类SGLT1和SGLT2的IC(50)值分别为5.6μM和2nM。在正常大鼠和狗体内,EGT1442能产生饱和的尿糖排泄,其ED(50)分别为0.38和0.09mg/kg。此外,EGT1442在体内外实验中均表现出良好的特性,对于2型糖尿病患者的管理可能具有积极作用。
Bexagliflozin,又称EGT1442,是一种高效且选择性的SGLT2抑制剂,能够降低db/db小鼠的血糖和HbA(1c)水平,同时延长易患中风大鼠的存活时间。EGT1442针对人类SGLT1和SGLT2的IC(50)值分别为5.6μM和2nM。在正常大鼠和狗体内,EGT1442能产生饱和的尿糖排泄,其ED(50)分别为0.38和0.09mg/kg。此外,EGT1442在体内外实验中均表现出良好的特性,对于2型糖尿病患者的管理可能具有积极作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Bexagliflozin (also known as EGT1442) is a potent and selective SGLT2 inhibitor that effectively reduces blood glucose and HbA(1c) levels in db/db mice while increasing the survival time of stroke-prone rats. The IC(50) values of EGT1442 for human SGLT1 and SGLT2 are 5.6 μM and 2 nM, respectively. In studies involving normal rats and dogs, EGT1442 induces saturated urinary glucose excretion with ED(50) values of 0.38 mg/kg and 0.09 mg/kg, respectively. Additionally, EGT1442 exhibits favorable properties in both in vivo and in vitro studies, indicating its potential positive impact on the management of type 2 diabetes. |
别名 | EGT-1442 diproline, EGT-0001442 diproline, 73J587R71C |
分子量 | 695.2 |
分子式 | C34H47ClN2O11 |
CAS No. | 1118567-48-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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