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SMARCA2-IN-6为SMARCA2 (亦作BRM) 抑制剂,其针对SMARCA2与SMARCA4的IC50低于5 nM。此外,SMARCA2-IN-6可抑制H1299细胞中的KRT80基因的表达(IC50:26 nM),并且能够抑制存在BRG1突变的SKMEL5细胞的增殖(IC50:13 nM)。
SMARCA2-IN-6为SMARCA2 (亦作BRM) 抑制剂,其针对SMARCA2与SMARCA4的IC50低于5 nM。此外,SMARCA2-IN-6可抑制H1299细胞中的KRT80基因的表达(IC50:26 nM),并且能够抑制存在BRG1突变的SKMEL5细胞的增殖(IC50:13 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM. |
分子量 | 319.72 |
分子式 | C10H8ClF2N5OS |
CAS No. | 2270875-79-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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