PB2

Name: PB2
Brand: TargetMol
SKU: T35889
Rating: 4.5 (1 reviews)

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产品编号 T35889Cas号 914940-24-2

PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].

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PB2

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产品编号 T35889Cas号 914940-24-2

规格	价格	库存
2 mg	¥ 984	5日内发货
5 mg	¥ 1,660	5日内发货
10 mg	¥ 2,890	5日内发货
25 mg	¥ 5,940	5日内发货
1 mL x 10 mM (in DMSO)	¥ 1,830	5日内发货

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产品介绍

生物活性

产品描述	PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].
体外活性	PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1].PB2 has modifications that neutralize the polarity of the compounds. The methylesters of PB2 is likely to be cleaved by cytosolic esterases, yielding a polar intracellular intermediate that would be unlikely to cross cell membranes[1].

化学信息

分子量	286.12
分子式	C₁₆H₂₀BO₂P
CAS No.	914940-24-2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (349.52 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4950 mL	17.4752 mL	34.9504 mL	174.7519 mL
5 mM	0.6990 mL	3.4950 mL	6.9901 mL	34.9504 mL
10 mM	0.3495 mL	1.7475 mL	3.4950 mL	17.4752 mL
20 mM	0.1748 mL	0.8738 mL	1.7475 mL	8.7376 mL
50 mM	0.0699 mL	0.3495 mL	0.6990 mL	3.4950 mL
100 mM	0.0350 mL	0.1748 mL	0.3495 mL	1.7475 mL