GNE-616

Name: GNE-616
Brand: TargetMol
SKU: T11439
Rating: 4.5 (1 reviews)

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产品编号 T11439Cas号 2349371-81-7

GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain.

GNE-616

还可以

产品编号 T11439Cas号 2349371-81-7

GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain.

规格	价格	库存
25 mg	¥ 22,700	10-14周
50 mg	¥ 30,300	10-14周
100 mg	¥ 39,500	10-14周

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产品介绍

生物活性

产品描述	GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain.
靶点活性	Nav1.6 (human):29 nM (ki), Nav1.2 (human):12 nM (ki), Nav1.7 (human): kd:0.38 nM , Nav1.7 (human):ki:0.79 nM
体外活性	Site-directed mutagenesis is critical for the isoform selectivity profile of GNE-616.
体内活性	GNE-616 shows robust activity in a Nav1.7-dependent inherited erythromelalgia (IEM) PK/PD model.