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Cirtuvivint (SM08502) 是一种有效且具有口服活性的 CDC 样激酶 (CLK) 抑制剂,可用于研究关节炎。
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Cirtuvivint (SM08502) 是一种有效且具有口服活性的 CDC 样激酶 (CLK) 抑制剂,可用于研究关节炎。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,060 | 现货 | |
5 mg | ¥ 2,650 | 现货 | |
10 mg | ¥ 3,980 | 现货 | |
25 mg | ¥ 6,270 | 现货 | |
50 mg | ¥ 8,460 | 现货 | |
100 mg | ¥ 11,300 | 现货 | |
200 mg | ¥ 15,300 | 现货 |
产品描述 | Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis. |
体外活性 | Inhibiting serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity, Cirtuvivint (SM08502) is associated with the inhibition of Wnt pathway-related gene and protein expression. Cirtuvivint induces the generation of splicing variants of Wnt pathway genes, suggesting that its mechanism for inhibiting gene expression includes effects on alternative splicing[1]. |
体内活性 | Significantly inhibiting the growth of gastrointestinal tumors, orally administered Cirtuvivint (SM08502) decreases SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models[1]. |
别名 | SM08502 |
分子量 | 427.5 |
分子式 | C24H25N7O |
CAS No. | 2143917-62-6 |
Smiles | CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 6 mg/mL (14.04 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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