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TL13-22是一种高效的间变性淋巴瘤激酶(Anaplastic Lymphoma Kinase, ALK)抑制剂,其IC₅₀值为0.54 nM,并且不会导致ALK蛋白的降解。TL13-22常被用作TL13-12(诱导ALK蛋白降解)的阴性对照。TL13-22还能促使其他激酶降解,包括Aurora A、FER、PTK2和RPS6KA1。
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TL13-22是一种高效的间变性淋巴瘤激酶(Anaplastic Lymphoma Kinase, ALK)抑制剂,其IC₅₀值为0.54 nM,并且不会导致ALK蛋白的降解。TL13-22常被用作TL13-12(诱导ALK蛋白降解)的阴性对照。TL13-22还能促使其他激酶降解,包括Aurora A、FER、PTK2和RPS6KA1。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 3,120 | 现货 | |
5 mg | ¥ 7,280 | 现货 | |
10 mg | ¥ 9,790 | 现货 | |
25 mg | ¥ 14,500 | 现货 | |
50 mg | ¥ 19,600 | 现货 |
产品描述 | TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1. |
靶点活性 | ALK:0.54 nM |
体外活性 | TL13-22促使Aurora A,FER,PTK2和RPS6KA1激酶降价的浓度分别为11.3,5.74,18.4和65.9 nM。[1] |
别名 | TL 13-22 |
分子量 | 947.5 |
分子式 | C45H55ClN10O9S |
CAS No. | 2229036-65-9 |
Smiles | O=C1C=2C=CC=C(NCC(=O)NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C(Cl)C(=N5)NC=6C=CC=CC6S(=O)(=O)C(C)C)C(OC)=C4)CC3)C2C(=O)N1C7C(=O)NCCC7 |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 200 mg/mL (211.08 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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