Integrin modulator 1

Name: Integrin modulator 1
Brand: TargetMol
SKU: T36291
Rating: 4.5 (1 reviews)

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产品编号 T36291Cas号 2023788-32-9

Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].

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Integrin modulator 1

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产品编号 T36291Cas号 2023788-32-9

规格	价格	库存
2 mg	¥ 2,480	5日内发货
5 mg	¥ 2,890	5日内发货
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 3,180	5日内发货

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产品介绍

生物活性

产品描述	Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].
靶点活性	α4β1:9.8 nM (IC50)
体外活性	Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner[1].

化学信息

分子量	262.26
分子式	C₁₃H₁₄N₂O₄
CAS No.	2023788-32-9
密度	1.413 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (381.3 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8130 mL	19.0650 mL	38.1301 mL	190.6505 mL
5 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
10 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
20 mM	0.1907 mL	0.9533 mL	1.9065 mL	9.5325 mL
50 mM	0.0763 mL	0.3813 mL	0.7626 mL	3.8130 mL
100 mM	0.0381 mL	0.1907 mL	0.3813 mL	1.9065 mL